Sunday, December 3, 2023

Frontline Combo Spot-on Cats - Anti-Flea and Anti-Tick Drops

 Frontline Combo Spot-on Cats is a highly effective, non-prescription veterinary medicine designed to combat flea and tick infestations in cats and domestic ferrets. This drop-on solution offers a convenient and potent solution for the treatment and control of these ectoparasites.


  • Each 0.5 ml pipette contains:

    • Fipronil – 50.00 mg
    • (S)-methoprene – 60.00 mg
  • Excipients:

    • Butylhydroxyanisole (E320) – 0.10 mg
    • Butylhydroxytoluene (E321) – 0.05 mg
    • Ethanol
    • Polysorbate 80 (E433)
    • Povidone
    • Diethylene glycol monoethyl ether

Pharmaceutical Form:

Solution for instillation on the skin. Transparent, yellow liquid.

Target Species:

Cats and domestic ferrets.


For Cats:

  • Treatment and control of flea infestations.
  • Control of mixed flea and tick and/or lice infestations.
  • Extermination of fleas (Ctenocephalides spp.) lasting 4 weeks.
  • Control of flea reproduction, inhibiting egg, larva, and pupa development.
  • Extermination of ticks (Ixodes ricinus, Dermacentor variabilis, Rhipicephalus sanguineus) lasting 2 weeks.
  • Destruction of lice (Felicola subrostratus).
  • Suitable for flea allergic dermatitis treatment.

For Domestic Ferrets:

  • Control of flea and mixed flea and tick infestations.
  • Treatment of flea infestation lasting 4 weeks.
  • Control of flea reproduction, inhibiting egg, larva, and pupa development.
  • Treatment of tick infestation lasting 4 weeks.


  • Not for use in kittens under 8 weeks or weighing less than 1 kg.
  • Avoid use in ferrets under 6 months.
  • Do not use in sick animals or during the recovery period.
  • Avoid use in case of increased sensitivity to active substances or excipients.
  • Not for use in rabbits.
  • Do not use in species other than indicated target species.


  • Avoid contact with the eyes.
  • Ensure application in areas inaccessible to licking.
  • Effectiveness may be affected by washing; avoid washing or wetting cats for 2 days after application.
  • Treat the animal's surroundings in cases of mass infestation.
  • No toxicity data for kittens whose mothers used this drug.

Precautions for Use:

  • Avoid oral mucosa and eye contact.
  • Individuals sensitive to insecticides or alcohol should avoid contact.
  • Do not smoke, drink, or eat during treatment.
  • Treated animals should not be petted until dry, and children should avoid contact.

Possible Side Effects:

  • Temporary salivation if licked.
  • Rare skin reactions, localized or generalized pruritus, or alopecia.
  • In extreme cases, hypersalivation, depression, neurological symptoms, vomiting, or respiratory symptoms may occur if swallowed.

Use During Pregnancy and Lactation:

  • Safe for use during pregnancy and lactation in cats.
  • Assess benefit/risk for pregnant ferrets before treatment.

Dosage and Administration:

  • Apply 0.5 ml pipette directly on the skin at the base of the neck.
  • Minimum interval of use is 4 weeks.


  • No adverse effects observed in cats at five times the recommended dose for 6 months.
  • Overdose may increase the risk of observed side effects.
  • Itching may occur but is temporary.

Pharmacological Properties:

  • Pharmacotherapeutic group: Ectoparasitic agents for local use, including insecticides.
  • Fipronil is an insecticide and acaricide.
  • (S)-methoprene is an insect growth regulator.

Pharmacokinetic Data:

  • Fipronil is well absorbed, quickly reaches peak concentration, and has a half-life of about 25 hours.
  • (S)-methoprene is well distributed and persists for at least 59 days.
  • Parasites mostly die through contact.

Pharmacological Incompatibility:

  • No established incompatibility between fipronil and (S)-methoprene.

For the complete and accurate usage of this product, please refer to the detailed instructions provided. Always consult with a veterinarian for specific concerns or questions related to your pet's health.

Non-Prescription Veterinary Medicine

Registration Number: VA - 072463/3

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