Frontline Combo Spot-on Cats - Anti-Flea and Anti-Tick Drops

 Frontline Combo Spot-on Cats is a highly effective, non-prescription veterinary medicine designed to combat flea and tick infestations in cats and domestic ferrets. This drop-on solution offers a convenient and potent solution for the treatment and control of these ectoparasites.

Composition:

• Each 0.5 ml pipette contains:

  • Fipronil – 50.00 mg
  • (S)-methoprene – 60.00 mg

• Excipients:

  • Butylhydroxyanisole (E320) – 0.10 mg
  • Butylhydroxytoluene (E321) – 0.05 mg
  • Ethanol
  • Polysorbate 80 (E433)
  • Povidone
  • Diethylene glycol monoethyl ether

Pharmaceutical Form:

Solution for instillation on the skin. Transparent, yellow liquid.

Target Species:

Cats and domestic ferrets.

Indications:

For Cats:

• Treatment and control of flea infestations.
• Control of mixed flea and tick and/or lice infestations.
• Extermination of fleas (Ctenocephalides spp.) lasting 4 weeks.
• Control of flea reproduction, inhibiting egg, larva, and pupa development.
• Extermination of ticks (Ixodes ricinus, Dermacentor variabilis, Rhipicephalus sanguineus) lasting 2 weeks.
• Destruction of lice (Felicola subrostratus).
• Suitable for flea allergic dermatitis treatment.

For Domestic Ferrets:

• Control of flea and mixed flea and tick infestations.
• Treatment of flea infestation lasting 4 weeks.
• Control of flea reproduction, inhibiting egg, larva, and pupa development.
• Treatment of tick infestation lasting 4 weeks.

Contraindications:

• Not for use in kittens under 8 weeks or weighing less than 1 kg.
• Avoid use in ferrets under 6 months.
• Do not use in sick animals or during the recovery period.
• Avoid use in case of increased sensitivity to active substances or excipients.
• Not for use in rabbits.
• Do not use in species other than indicated target species.

Warnings:

• Avoid contact with the eyes.
• Ensure application in areas inaccessible to licking.
• Effectiveness may be affected by washing; avoid washing or wetting cats for 2 days after application.
• Treat the animal's surroundings in cases of mass infestation.
• No toxicity data for kittens whose mothers used this drug.

Precautions for Use:

• Avoid oral mucosa and eye contact.
• Individuals sensitive to insecticides or alcohol should avoid contact.
• Do not smoke, drink, or eat during treatment.
• Treated animals should not be petted until dry, and children should avoid contact.

Possible Side Effects:

• Temporary salivation if licked.
• Rare skin reactions, localized or generalized pruritus, or alopecia.
• In extreme cases, hypersalivation, depression, neurological symptoms, vomiting, or respiratory symptoms may occur if swallowed.

Use During Pregnancy and Lactation:

• Safe for use during pregnancy and lactation in cats.
• Assess benefit/risk for pregnant ferrets before treatment.

Dosage and Administration:

• Apply 0.5 ml pipette directly on the skin at the base of the neck.
• Minimum interval of use is 4 weeks.

Sale:

• No adverse effects observed in cats at five times the recommended dose for 6 months.
• Overdose may increase the risk of observed side effects.
• Itching may occur but is temporary.

Pharmacological Properties:

• Pharmacotherapeutic group: Ectoparasitic agents for local use, including insecticides.
• Fipronil is an insecticide and acaricide.
• (S)-methoprene is an insect growth regulator.

Pharmacokinetic Data:

• Fipronil is well absorbed, quickly reaches peak concentration, and has a half-life of about 25 hours.
• (S)-methoprene is well distributed and persists for at least 59 days.
• Parasites mostly die through contact.

Pharmacological Incompatibility:

• No established incompatibility between fipronil and (S)-methoprene.

For the complete and accurate usage of this product, please refer to the detailed instructions provided. Always consult with a veterinarian for specific concerns or questions related to your pet's health.

Non-Prescription Veterinary Medicine

Registration Number: VA - 072463/3